Towards trajectory anonymization: A generalization-based approach

Trajectory datasets are becoming,popular,due,to the massive,usage,of GPS and,location- based services. In this paper, we address privacy issues regarding the identification of individuals in static trajectory datasets. We first adopt the notion of k-anonymity,to trajectories and propose,a novel generalization-based approach,for anonymization,of trajectories. We further show,that releasing anonymized,trajectories may,still have,some,privacy,leaks. Therefore we propose,a randomization based,reconstruction,algorithm,for releasing anonymized,trajectory data and,also present how,the underlying,techniques,can be adapted,to other anonymity,standards. The experimental,results on real and,synthetic trajectory datasets show,the effectiveness of the proposed,techniques

On non-L2L^2 solutions to the Seiberg-Witten equations

We show that a previous paper of Freund describing a solution to the Seiberg-Witten equations has a sign error rendering it a solution to a related but different set of equations. The non-$L^2$ nature of Freund's solution is discussed and clarified and we also construct a whole class of solutions to the Seiberg-Witten equations.Comment: 8 pages, Te

Stabilizing role of platelet P2Y(12) receptors in shear-dependent thrombus formation on ruptured plaques

Background: In most models of experimental thrombosis, healthy blood vessels are damaged. This results in the formation of a platelet thrombus that is stabilized by ADP signaling via P2Y(12) receptors. However, such models do not predict involvement of P2Y(12) in the clinically relevant situation of thrombosis upon rupture of atherosclerotic plaques. We investigated the role of P2Y(12) in thrombus formation on (collagen-containing) atherosclerotic plaques in vitro and in vivo, by using a novel mouse model of atherothrombosis. Methodology: Plaques in the carotid arteries from Apoe(-/-) mice were acutely ruptured by ultrasound treatment, and the thrombotic process was monitored via intravital fluorescence microscopy. Thrombus formation in vitro was assessed in mouse and human blood perfused over collagen or plaque material under variable conditions of shear rate and coagulation. Effects of two reversible P2Y(12) blockers, ticagrelor (AZD6140) and cangrelor (AR-C69931MX), were investigated. Principal Findings: Acute plaque rupture by ultrasound treatment provoked rapid formation of non-occlusive thrombi, which were smaller in size and unstable in the presence of P2Y(12) blockers. In vitro, when mouse or human blood was perfused over collagen or atherosclerotic plaque material, blockage or deficiency of P2Y(12) reduced the thrombi and increased embolization events. These P2Y(12) effects were present at shear rates >500 s(-1), and they persisted in the presence of coagulation. P2Y(12)-dependent thrombus stabilization was accompanied by increased fibrin(ogen) binding. Conclusions/Significance: Platelet P2Y(12) receptors play a crucial role in the stabilization of thrombi formed on atherosclerotic plaques. This P2Y(12) function is restricted to high shear flow conditions, and is preserved in the presence of coagulation

A Quasiperiodic Gibbons--Hawking Metric and Spacetime Foam

We present a quasiperiodic self-dual metric of the Gibbons--Hawking type with one gravitational instanton per spacetime cell. The solution, based on an adaptation of Weierstrassian $\zeta$ and $\sigma$ functions to three dimensions, conforms to a definition of spacetime foam given by Hawking.Comment: 14 pages, Late

N=2 Supersymmetric Model with Dirac-Kahler Fermions from Generalized Gauge Theory in Two Dimensions

We investigate the generalized gauge theory which has been proposed previously and show that in two dimensions the instanton gauge fixing of the generalized topological Yang-Mills action leads to a twisted N=2 supersymmetric action. We have found that the R-symmetry of N=2 supersymmetry can be identified with the flavour symmetry of Dirac-Kahler fermion formulation. Thus the procedure of twist allows topological ghost fields to be interpreted as the Dirac-Kahler matter fermions.Comment: 22 pages, LaTe

Potentiation of thrombus instability: a contributory mechanism to the effectiveness of antithrombotic medications

© The Author(s) 2018The stability of an arterial thrombus, determined by its structure and ability to resist endogenous fibrinolysis, is a major determinant of the extent of infarction that results from coronary or cerebrovascular thrombosis. There is ample evidence from both laboratory and clinical studies to suggest that in addition to inhibiting platelet aggregation, antithrombotic medications have shear-dependent effects, potentiating thrombus fragility and/or enhancing endogenous fibrinolysis. Such shear-dependent effects, potentiating the fragility of the growing thrombus and/or enhancing endogenous thrombolytic activity, likely contribute to the clinical effectiveness of such medications. It is not clear how much these effects relate to the measured inhibition of platelet aggregation in response to specific agonists. These effects are observable only with techniques that subject the growing thrombus to arterial flow and shear conditions. The effects of antithrombotic medications on thrombus stability and ways of assessing this are reviewed herein, and it is proposed that thrombus stability could become a new target for pharmacological intervention.Peer reviewedFinal Published versio

A Large Hadron Electron Collider at CERN

This document provides a brief overview of the recently published report on the design of the Large Hadron Electron Collider (LHeC), which comprises its physics programme, accelerator physics, technology and main detector concepts. The LHeC exploits and develops challenging, though principally existing, accelerator and detector technologies. This summary is complemented by brief illustrations of some of the highlights of the physics programme, which relies on a vastly extended kinematic range, luminosity and unprecedented precision in deep inelastic scattering. Illustrations are provided regarding high precision QCD, new physics (Higgs, SUSY) and electron-ion physics. The LHeC is designed to run synchronously with the LHC in the twenties and to achieve an integrated luminosity of O(100) fb$^{-1}$. It will become the cleanest high resolution microscope of mankind and will substantially extend as well as complement the investigation of the physics of the TeV energy scale, which has been enabled by the LHC

Status of the compactlight design study*

CompactLight (XLS) is an International Collaboration of 24 partners and 5 third parties, funded by the European Union through the Horizon 2020 Research and Innovation Programme. The main goal of the project, which started in January 2018 with a duration of 36 months, is the design of an hard X-ray FEL facility beyond today’s state of the art, using the latest concepts for bright electron photo-injectors, high-gradient accelerating structures, and innovative short-period undulators. The specifications of the facility and the parameters of the future FEL are driven by the demands of potential users and the associated science cases. In this paper we will give an overview on the ongoing activities and the major results achieved until now